A Holistic Approach to Endometriosis
Artist Amedeo Modigliani Title Caryatid Place Italy.
For many years, I suffered from endometriosis. I had to go through various fertility treatments when we tried to get pregnant, had miscarriages and eventually a total hysterectomy. That’s when the pain and discomfort ended for me, but the psychological impact is still with me today. Endometriosis is a life-altering condition and definitely not just heavy and painful periods.
According to Endometriosis UK, 10% of women of reproductive age in the UK suffer from endometriosis, one of the most common gynaecological conditions.
Endometriosis is a highly complex disease, where cells like the ones you find in the lining of the uterus are growing elsewhere in the body, for example, inside the pelvis, on the bowel, or inside the muscle of the womb. These cells respond to hormones in the same way the cells in the uterus lining do, so at some point during the monthly cycle, they grow, break down and bleed. But because the blood can’t leave the body, it is causing pain, inflammation, swelling, and it forms adhesions (scar tissue).
Typical symptoms of endometriosis are painful periods, painful sex, and infertility. But that is not all, some women experience very heavy bleeding, fatigue, depression, nausea, irritable bowel-like symptoms such as constipation and bloating, etc. Some women have no symptoms at all. Unfortunately, the condition is poorly understood, and there are several theories on what is causing it. One of the theories is that endometriosis is caused by ‘retrograde menstruation’, where menstrual blood/tissue flows backwards through the fallopian tubes into the pelvis and implants itself. Other theories on the cause of endometriosis are immune dysfunction, lymphatic spread, exposure to environmental toxins, genetics, inflammation, etc.
What can be done about endometriosis?
Typical treatment for endometriosis is pain management, and/or hormone treatment and if these fail, then surgery in the form of ‘excision’ is the next option. A specialised endometriosis surgeon will remove the endometriosis lesions.
It is often thought that a hysterectomy (removal of the uterus and sometimes ovaries too) will cure endometriosis. My friend, consultant gynaecologist and endometriosis surgeon Dr Shaheen Khazali once explained to me that removing the uterus doesn’t treat endometriosis, but that there are situations where it could be beneficial. For instance, in cases of ‘adenomyosis’, where the endometriosis can be found inside the muscle of the uterus. As with all medical conditions, it depends on the patient’s individual situation.
Complementary medicine has been helpful for the support of endometriosis sufferers. Think of nutritional therapy, acupuncture, massage or herbal medicine for pain relief, hormone balancing etc. There are various areas that nutritional therapy can target, that would be helpful for endometriosis.
Hormone-balancing
Addressing inflammation
Enhancing the immune system
Reduce your plastic exposure as much as possible.
A. Hormone Balancing
As endometriosis is an oestrogen-dependent disorder, balancing hormones is very important. Endometriosis produces its own oestrogen. Controlling excess oestrogen can be achieved by making sure there is optimal gut health and good detoxication, so your body can get rid of excess oestrogen and toxins. It is also important to reduce exposure to environmental toxins, such as pesticides, plastics, cleaning products etc. These hormone disruptors can alter hormone functions by mimicking oestrogens for instance.
Optimal Gut Health
Eliminate constipation by:
avoiding processed foods
eating a wide variety of fibre-rich, plant-based foods
eating healthy fats such as ghee, coconut oil, organic butter, olive oil, nuts & seeds
fermented foods like natural yoghurt
Good Detoxification
Optimal gut health is a good start to healthy detoxification. The liver detoxifies excess oestrogen, so if your liver is not working optimally, the oestrogen will get reabsorbed.
Foods for detox:
Cruciferous vegetables such as kale, broccoli, Brussels sprouts, and cauliflower
Cabbage
Red peppers
Garlic and onions
Green leafy vegetables
Turmeric, dill, rosemary
Green tea
Foods rich in vitamin B and C
It is important to decrease your exposure to toxins. Eat organic foods, when possible, reduce the use of plastics etc. and investigate changing your household cleaning products into eco-friendly products such as Ecover, Earth Friendly or Ecozone. Also, use environmentally friendly cosmetics and body products, and if you use tampons, buy 100% organic ones that are free of dioxin and other chemicals.
Some chemicals to look out for in products: Sodium Lauryl/Laureth Sulphate, Phthalates (watch out for any names ending in phthalate, sometimes shortened to DBP, DEHP, BBP and BzBP), Parabens, Formaldehyde, Petrolatum (i.e. baby oil is 100% mineral oil - a by-product of petroleum)
Inhibiting aromatase
Aromatase is an enzyme that is involved in the production of oestrogen. Endometriosis tissue contains very high levels of aromatase. Foods containing phytoestrogens such as lignans and flavonoids are natural aromatase inhibitors :
Flaxseeds (for best bioavailability, use crushed or milled)
Sesame seeds
Vegetables and fruit (especially citrus fruits, apples and berries)
Legumes
Tea (black and green)
Chocolate (especially dark, at least 80% cocoa)
Please note:
- Whole grains are a good source of lignans, but they can be inflammatory!
- Red wine is a good source of flavonoids, but alcohol doesn’t help detoxification and can cause inflammation
As inflammation stimulates aromatase, it is important to reduce any inflammation.
Weight Management
Visceral adipose tissue is a hormonally active component of your total body fat. It is the fat that is wrapped around the organs in the abdomen (liver, pancreas etc.). Visceral fat is active and releases pro-inflammatory chemicals and other toxic substances. These fat cells also contain aromatase, so more oestrogen can be produced. To make matters worse, these visceral fat cells can store environmental toxins. To reduce inflammation and excess oestrogen, avoiding being overweight is essential.
B. Addressing Chronic Inflammation
Endometriosis is an inflammatory disease; hence, it is vital to reduce inflammation as much as possible. Following an anti-inflammatory diet is key:
Foods to Avoid
1. Processed and refined foods
2. Sugar
3. Gluten
Research has shown that there is a link between endometriosis and Coeliac Disease , and that 12 months on a gluten-free diet can reduce painful endometriosis symptoms.
4. Oxidised fats (i.e. vegetable oils) and trans fats (i.e. margarine, fried foods)
5. Dairy products
Dairy products are a source of excess hormones (i.e. growth factors), antibiotics, steroids and, pesticides, that might have physiological effects in humans.
6. Excess caffeine and alcohol
What can you eat?
Good quality protein (lean, organic, preferably grass-fed meat, wild meat, game, and wild-caught, fresh fish such as salmon, trout or sardines)
Complex carbohydrates (vegetables, fibre-rich fruit, legumes, pulses)
A ‘rainbow’ of different coloured vegetables and fruit daily
Generous helpings of cruciferous vegetables (broccoli, cauliflower, cabbage, Brussels sprouts etc.) and dark green leafy vegetables (kale, spinach, watercress, rocket etc.
Herbs & spices (turmeric, ginger, cloves, cinnamon, rosemary, oregano, sage, thyme)
Healthy oils & fats (coconut oil, olive oil, ghee, avocado, nuts and seeds, oily fish)
Essential Fatty Acids (oily fish, nuts and seeds, eggs)
Dairy alternatives such as almond, hazelnut, hemp, coconut or oat milk and yoghurt
Fermented foods such as sauerkraut, kimchi and miso
Green tea
Shiitake mushrooms
Bone broth made with organic bones
Apart from following an anti-inflammatory diet, it is also essential to reduce environmental toxins, as these can trigger inflammation. Managing stress is another factor to deal with, since stress influences how the body regulates inflammation.
C. Enhancing the Immune System
Various studies have shown changes in the immune system that play a role in the survival and growth of displaced menstrual tissues in women with endometriosis. As endometriosis is considered a disease of immune dysregulation, enhancing the immune system could be beneficial.
To function optimally, the immune system requires:
A good, nutrient-dense diet
Optimal gut health
Adequate sleep (6- 8 hours)
Relaxation
Regular exercise (be careful, as excessive exercise can have the opposite effect!)
Factors the immune system can do without:
Lack of nutrients
Lack of sleep
Excess weight
Prolonged stress
Foods that enhance immunity
All the foods mentioned before will be helpful in enhancing your immunity.
Make sure you get plenty of antioxidants that improve the function of the immune system and protect your cells from damage caused by free radicals. Foods that are high in antioxidants are, for example, brightly coloured vegetables and fruits (‘eat a rainbow’) and vitamin A-rich foods such as organic liver and eggs. Other immune-boosting nutrients are zinc (shellfish, grass-fed beef, legumes, egg yolks, sunflower and pumpkin seeds, ginger), vitamin C and vitamin E (nuts, seeds, green leafy vegetables).
Vitamin D deserves a special mention here as it can change immune responses. Good sources are oily fish and eggs.
Supplements
There are various supplements that could be beneficial for different symptoms of endometriosis, but as every woman is unique, it is hard to give a list that would suit all. However, there are some general supplements that are recommended:
A good multivitamin and mineral formula
Probiotics
Omega 3 Essential Fatty Acids: fish oil, or if you’re vegetarian/vegan algae oil
Vitamin D
If you would like a tailor-made protocol for endometriosis, contact a qualified and registered nutritional therapist.
References
Maulenkul, T., Kuandyk, A., Makhadiyeva, D. et al. Understanding the impact of endometriosis on women’s life: an integrative review of systematic reviews. BMC Women's Health 24, 524 (2024). https://doi.org/10.1186/s12905-024-03369-5
Tragantzopoulou P. Endometriosis and stigmatization: A literature review. Journal of Endometriosis and Pelvic Pain Disorders. 2024;16(2):117-122.
https://journals.sagepub.com/doi/epub/10.1177/22840265241248488Goleij, P., Khandan, M. et al. Unlocking the Potential: How Flavonoids Affect Angiogenesis, Oxidative Stress, Inflammation, Proliferation, Invasion, and Alter Receptor Interactions in Endometriosis. Food Science & Nutrition: Volume 13, Issue 1(2025)
Ashish A, Mishra S, et al. Advances in Endometriosis Research: From Pathogenesis to Prevention. A Comprehensive Overview of Endometriosis. IntechOpen (2024) http://dx.doi.org/10.5772/intechopen.1007830
Szczepanik J, Dłużewska M. The Importance of Diet in the Treatment of Endometriosis. Women. (2024) 4(4):453-468.
https://doi.org/10.3390/women4040034Hearn-Yeates, F., Horne, A. W. et al. Microbiome: The impact of the microbiota–gut–brain axis on endometriosis-associated symptoms: mechanisms and opportunities for personalised management strategies. Reproduction and Fertility, 5(2), e230085. (2024) https://doi.org/10.1530/RAF-23-0085
Patel, M. Recent Trends in Medical Management of Endometriosis. J Obstet Gynecol India 74, 479–483. (2024)
https://doi.org/10.1007/s13224-024-02097-yPeng, Y., Li, Y. et al. Causality of immune cells and endometriosis: a bidirectional mendelian randomization study. BMC Women's Health, 24(1), 574. (2024)
https://link.springer.com/article/10.1186/s12905-024-03417-0Sherwani, S., Khan, M. et al. The vicious cycle of chronic endometriosis and depression—an immunological and physiological perspective. Frontiers in Medicine, 11, 1425691. (2024)
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1425691/full
Abulughod, N., Valakas, S., & El-Assaad, F. Dietary and Nutritional Interventions for the Management of Endometriosis. Nutrients, 16(23), 3988. (2024) https://doi.org/10.3390/nu16233988